Imprinting: perinatal exposures cause the development of diseases during the adult age.

...perinatal exposure to several substances may induce irreversible alterations, that can be detected later in life. 

[ Possible Irreversable alteration in a child ]

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Subject:    Imprinting: perinatal exposures cause the development of diseases during the adult age.
 Date:        Mon, 08 Jan 2001 17:25:30 -0500
From:        Stephen Tvedten <steve@getipm.com>
Organization:     Get Set Inc. (www.getipm.com)

To:     Paul Helliker <phelliker@cdpr.ca.gov>
          Director, State of California, Department of Pesticide Regulation 

cc:    Carol Browner browner.carol@epa.gov

Dear Mr. Helliker,  I thought you might like to see an article DMREILLY sent me entitled: Imprinting: perinatal exposures cause the development of diseases during the adult age.

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1: Acta Biol Hung 1999;50(4):425-40 - Imprinting: perinatal exposures cause the development of diseases during the adult age.  -  Tchernitchin AN, Tchernitchin NN, Mena MA, Unda C, Soto J  -  Laboratory of Experimental Endocrinology and Environmental Pathology LEEPA, University of Chile, Medical School, Santiago. atcherni@machi.med.uchile.cl

Since the early reports linking the development of clear cell cervicovaginal adenocarcinoma in young women with diethylstilbestrol treatment of their mothers during pregnancy, it became clear that perinatal exposure to several substances may induce irreversible alterations, that can be detected later in life. Current evidence suggests that these substances induce, by the mechanism of imprinting, alterations of the differentiation of several cell-types, resulting in the development of disease during the adult age. The most known delayed effects to prenatal exposure to agents displaying hormone action, pollutants, food additives and natural food components, substances of abuse and stress by the mechanism of imprinting are described. Among them, estrogens, androgens, progestins, lead, benzopyrenes, ozone, dioxins, DDT, DDE, methoxychlor, chlordecone, parathion, malathion, polychlorobiphenyls, pyrethroids, paraquat, food additives, normal food constituents, tetrahydrocannabinol, cocaine and opiates. It is concluded that perinatal exposure to several agents causes irreversible changes that determine health conditions during adulthood. Several diseases developing during adulthood probably were determined during early stages of life, under the effect of exposure or preferential mother's diet during pregnancy. Regulations to avoid these early exposures may contribute to an important improvement of health conditions of humankind.

Publication Types:
*   Review
*   Review, academic
PMID: 10735177, UI: 20197224

Well Mr. Helliker, It would seem that your Department of Pesticide Regulations might like to pay attention to the last line of this report, that is, if you really want to improve the health of mankind.  Your "registered" POISONS have never been studied adequately and we and the unborn are your "guinea pigs".  When will it be "legal" (in your opinion) to use safe and far more effective (unregistered) alternatives?  Can the profits of the POISON "industry" really be worth all of this needless suffering?

Respectfully,  Stephen L. Tvedten

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[Editor's Note:  Dr. Janette Sherman has covered this topic in her books.  Click Here for more information.]

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