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The Global Scope of Chemical Exposures in our 21st Century Environment: Indoors and Outdoors

Article Contributions from Sue Kegley

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Dear Steve,

"In response, the editor of Chemical & Engineering News, the main trade magazine of the American Chemical Society noted that the only answer is to admit past egregious behavior and make public health data on the safety of chemicals for there must be no more secrets and lies (http://www.pubs.acs.org/cen)."

 Well, Steve, I checked out the Chemical & Engineering News web site mentioned by Dr. Seba, but when I tried to access items containing the words "Bill Moyers" (there are seven of them) I couldn't, because I don't have a subscriber number and password. If you have a way of accessing information on this web site, it might be worth seeing exactly what the CEN editor said. Of course, who knows whether his industry will do what he is suggesting.

 I read this e-mail with interest and do have access to the ACS web site.  I went and pulled down the relevant documents. The Secrets and Lies editorial is first, written by the editor, Madeline Jacobs.  Next is a collection of letters to the editor that came in on the issue, including one I wrote with several other friends of mine who are also chemists and are also disgusted with the behavior of the chemical industry and the oily scum that rubs off of them on onto the rest of us chemists who are trying to protect human health and clean up the environment. There were 8 letters to the editor about the issue---7 of them basically said it's time to clean up the act of the chemical industry and admit that there were (and are) problems and do something to fix them.  One letter was from someone in St. Louis, MO (Monsanto's home town) with a predictable pro-industry perspective.

A point worth taking from this collection of letters is that activists have many allies in the field of chemistry.  In my 15 years of experience teaching chemistry in a university setting and interacting with other academic chemists and bench chemists in industry, I found that the majority of people are concerned about the environment and the damage chemicals have done to human health.  The academics are taking steps to educate students about environmental problems, their causes and solutions. There are many who are avidly anti-corporate who would welcome the opportunity to work with advocacy groups to provide research (for free in many cases) to back up points we suspect are true, but don't have the resources to collect the data.  In my experience, the truly evil don't-give-a-damn, screw-the-environment, this-stuff-won't-hurt-you-what-are-you-worried-about chemists certainly exist, but are not the norm, particularly in academic settings. The average chemist is just interested in how things work at the molecular level.  Fascinated (and frequently blinded) by this curiosity and wonder, these average chemists can, at worst, be accused of being unaware of the larger societal consequences of their experiments.  While this is not good, it's normal for the average human being to not look beyond their own back yard.  It's quite different in corporate settings, since industrial bench chemists have little power, and often a company will fire thousands of them in the space of 3 months because that quarter's profits are down.  But these are not the people in charge of the corporate decision-making that has resulted in so much pain, suffering, and degradation of the environment.  Most of the powerful leaders in the ACS probably never took a chemistry course in their lives. They have business degrees, and their only motive is the next quarter's profits.  THAT is the larger problem.

The letters to the editor were followed by a full-court press in subsequent weeks to recover from the damage. Articles included a Guest Editorial from Dennis Reilley, Chairman of the American Chemistry Council,  several by the editor Madeline Jacobs, and one from Attila Pavlath, ACS President, all trying to recover from the damage and cheer the members on to make sure the public understands how "important" and" beneficial" the chemical industry is to our society. Not a word about how the industry needs to own up to what it has done  and change its ways.  At this point, I got  disgusted with the whole enterprise and have not been following it lately, but I'm sure there has been more propaganda since.

I've appended all the articles, FYI.

Best,

Susan Kegley Pesticide Action Network

 EDITOR'S PAGE April 2, 2001 Volume 79, Number 14 CENEAR 79 14 pp.5 ISSN 0009-2347 [Next Story]

Secrets And Lies

 Madeleine Jacobs Editor-in-chief

Timing is everything in life, and the timing couldn't have been worse for me last week. I had been invited to speak at my grandson's high school about attracting the best and the brightest students into careers in chemistry. Unfortunately, my talk came on the heels of a damning indictment of the chemical industry in the form of a Bill Moyers PBS special titled "Trade Secrets" (see page 9). This 90-minute program, followed by a 30-minute roundtable discussion, contained excruciating detail about the serious health hazards associated with vinyl chloride and industry's attempts, decades ago, to hide the hazard from--indeed to lie to--its employees.

 In the Moyers report, we learn about chemical industry workers who died from exposure to chemicals. We see one of these workers, Dan Ross, die--through photographs taken of him after he was diagnosed with brain cancer linked to his exposure to vinyl chloride. We hear his widow, Elaine, tell Moyers: "They hurt somebody that meant more to me than my whole life. I would have gladly taken his place to die. Gladly."

Ross sued her husband's employer, Conoco. The lawsuit uncovered boxes of "secret" industry documents which show clearly that individual chemical companies and the chemical industry's trade association--now called the American Chemistry Council (ACC)--covered up the health effects of exposure to a variety of chemicals. We see documents dating back as far as 1959, and as recently as the early 1990s, in which the industry makes statements that are seemingly aimed at undermining its workers' and, ultimately, the general public's health.

I don't have space to tell you everything about this program or the roundtable discussion, which was the chemical industry's only opportunity to respond to Moyers' allegations. If you missed the program, PBS has an extensive website (http://www.pbs.org/tradesecrets/), where you can access the entire transcript of both the program and roundtable. ACC also has a website rebutting the program (http://www.abouttradesecrets.com/). I urge readers to visit both websites.

But I do have space for a few observations. The program dealt largely with decades-old information. It identified practices concerning employee health that, I sincerely hope, have been corrected by the chemical industry. It rehashed information that had been covered in a 1998 series of articles in the Houston Chronicle and in C&EN in the 1970s. And it did not ask anyone from industry to comment in the program itself, because, as Moyers explained during the roundtable, "investigative journalism is not a collaboration between the journalist and the subject."

ACC's representative on the roundtable made matters worse by initially attacking Moyers rather than leading with the eventual positive message that the chemical industry has corrected the problems and that chemicals and the chemical industry have made life better for people.

The program has severely damaged the chemical industry's reputation. I know this because the parents and kids at my grandson's school told me so. Indeed, who could miss the message of this program Here are Moyers' closing words: "Half a century into the chemical revolution, there is a lot we don't know about the tens of thousands of chemicals all around us. What we do know is that breast cancer has risen steadily over the last four decades ... brain cancer among children is up by 26% ... testicular cancer among older teenage boys has almost doubled ... infertility among young adults is up, and so are learning disabilities in children. We don't know why. But by the industry's own admission, very little data exist to prove chemicals safe. So we are flying blind. Except the laboratory mice in this vast chemical experiment are the children. They have no idea what's happening to them. And neither do we." This is a breathtaking non sequitur--extrapolating from unacceptable chemical exposure of workers decades ago to the conclusion that chemicals today are killing all of us and irrevocably damaging our children. The only real answer to a program of this kind is for industry to admit that its past practices were egregious and that there is still much to be learned about the safety of chemicals. The industry must continue to test chemicals and make public the resulting health data. There must be no more secrets and lies.

 LETTERS to the Editor May 7, 2001 Volume 79, Number 19 CENEAR 79 19 pp. 6-10 ISSN 0009-2347 [Previous Story] [Next Story]

I'm writing after viewing the recent Bill Moyers PBS special "Trade Secrets: A Moyers Report" (C&EN, April 2, pages 5 and 9). I worked as a process chemist in the chemical industry for three years prior to my return to graduate school for a Ph.D. I agree with the premise that the chemical industry still does things that are not environmentally benign, and which may impact the health of chemical industry workers and the general public. It seems that the Chemical Manufacturers Association-now the American Chemistry Council (ACC)-has lobbied continuously against regulations due mainly to economic concerns regarding compliance with safety and environmental regulations. Complying with new regulations may require expensive modifications of newer plants or shutdowns of older plants, and even cost-effective modifications can run in the millions of dollars.

All of us who have been associated with chemical processes know this to be the case. And the trend toward outsourcing of chemical production only shifts the burden to smaller companies that are less able to evaluate hazards effectively and, frankly, are less likely to protect their workers or the environment effectively. Visiting just a few low-cost tollers will convince anybody of this fact. But the trends continue as stockholders push for greater profits from chemical companies.

There is not an accepted method for evaluating information regarding subtle effects such as chronic environmental releases due to production or the environmental impact of new products versus older products. These things have costs to society, but not necessarily to chemical companies. Using cost to evaluate these items breaks down as a decision-making method at some point. But in essence, the release of chemicals to the environment is something that is not necessary and can be prevented-at a cost. It is a moral and ethical choice.

Can we rely on the chemical industry to draw the line on this issue when their profits are at stake? I don't believe that is the wisest choice. As a collection of individual scientists, separate from the profit motive, better decisions might be made and lobbied for. Our profession should start to take a stand on environmental issues, even if it involves fighting against our employers. Maybe we need a nationwide union of chemists and engineers who have the goal of ensuring that our chemical industry behaves as responsibly as possible, with respect to the environment and the people living in it. Would this be bad for the chemical industry? Possibly. But would it be good for chemists and society? Absolutely.

David Mosley Cambridge, Mass.

In discussing the recent editorial, I am not convinced that one can pin the words "secrets and lies" on anybody-either industry or PBS.

Nonscientists have been trying very hard to shift scientific discussion away from "peer-reviewed and published fact" to the area of polemic, self-developed ethics, hype, and exposé. Also, communications majors have done an excellent job and should be praised for that, and they control public opinion far more effectively than scientists do. Nevertheless, in the world of facts, words like "secrets," "lies," "hiding," and "cops and robbers" generally do not belong.

What are the facts? What is the EPA-published toxicity of vinyl chloride? What was it 10 years ago? Note that the EPA IRIS (Integrated Risk Information System) is public, transparent, and has references to every published study, yet nobody would think of taking toxicity data for hexavalent chromium from IRIS-they all take it from Hollywood films. To the extent that there are numbers, the nonscientific numbers are almost always at odds with those published in journals. This is what C&EN should research and publish and with references.

Leave words like "secrets and lies" to the paid nonscience communicators.

Edwin A. Matzner St. Louis

I just read Madeleine Jacobs' editorial "Secrets and Lies." We have to admit that there are people who lie and deceive, the chemical industry being no exception-neither is any other sector of business or human interaction free of the problem. Prime examples are Charles Keating Jr. (banking), Ivan Boesky and Michael Milken (stock brokerages), Richard Nixon and Spiro Agnew (politics), and Jim and Tammy Faye Bakker and Jimmy Swaggart (religion). A very good example of denial of the obvious and attempting to deceive the public is the cigarette industry. The list is endless. However, this does not excuse the actions of the individuals or corporations. The more responsibility and power a person or group has, the more they should be held accountable for their actions and penalized accordingly when they violate the public trust.

We need to take the blows, admit our mistakes, and move on. At the same time, we need to hold the irresponsible parties liable for their actions, regardless of the length of time between the crime and its discovery.

Tom Gardner Landenberg, Pa.

As a current graduate student in organic chemistry, I often find myself in a similar predicament to the one described in Jacobs' editorial. I find it increasingly difficult as a teaching assistant to demonstrate the importance of chemistry to encourage undergraduates to pursue a career in the chemical sciences. Despite the innumerable contributions chemists have made to improve the human condition, negative images of the chemical industry loom large in the mind of the public. From my perspective, two factors account for this trend: fear of the unknown and a perceived lack of corporate accountability.

People tend to fear that which they do not understand. Until society makes a real commitment to primary and secondary science education for all students, fear and misunderstanding will continue to drive public opinion of the chemical industry. The reader need not look any further than K. M. Reese's Newscripts section to see abundant examples of popular misconceptions of chemistry.

Although I did not see the PBS program, the information presented on the PBS and ACC websites paints a dismal picture. Individual and corporate conduct that were clearly criminal went largely unpunished. When companies are allowed to put profit ahead of human life, the public has obvious reason to be outraged. Unfortunately, misconduct by a tiny minority of the chemical industry shapes public perception of all chemical companies, even those that are rigorously committed to worker safety and environmental stewardship. Only when the responsible parties are held accountable will public trust be restored.

Kevin L. Greenman Irvine, Calif.

Moyers' PBS report provided us with a disturbing look at practices in the chemical industry that have a chilling likeness to events surrounding the downfall of the tobacco industry. With broad calls for congressional hearings on the chemical industry (see http://www.comeclean.org), perhaps it is time to rethink the efficacy of some long-standing practices.

We might hope that cover-ups and manipulation of information by some within the chemical industry are things of the past. Unfortunately, there is ample evidence that information is still concealed, results of "scientific" tests are distorted, and delays for "further study" are frequently thrown up as roadblocks to regulation. Thus, public right to know about the potential hazards of toxic chemicals is obstructed. While chemists are often blamed by the public, it is, in reality, the business/managerial end of the industry that provides the driving force for this behavior. Unfortunately, overly narrow focus on the bottom line can easily color issues of worker/consumer/environmental safety as mere economic obstacles to be overcome by whatever means.

Those concerned about the integrity of science should be alarmed. Certain elements within the chemical industry have violated the precepts of science by determining conclusions in advance and manipulating experiments and data until the results support claims that the risks associated with certain chemicals are acceptable. A scientist intent on knowing the truth would notice that there is a growing body of evidence linking chemical exposures to adverse effects on humans and the environment. With animal-based toxicity tests providing concrete evidence to support this hypothesis and epidemiologic studies showing increased age-adjusted incidence of human cancers and fertility problems associated with chemical exposures (see http://www.psrla.org/pesticides/pesticides_and_health_kit.pdf), we cannot responsibly ignore the possibility that chemicals are a larger part of the problem than was initially evident.

It's time for a change. For chemists, it means resisting pressure from management to do bad science. ACS should support them in these efforts. For companies that wish to avoid being discredited and sued to within an inch of their corporate lives-think tobacco industry here-this means delivering on Responsible Care by ensuring that toxicity information on all high-production-volume chemicals is made available to the public now. It means not blocking the release of EPA's dioxin report. It means disclosing information about hazardous chemicals to the public and regulatory agencies before it has to be extracted by court order. In the end, public health, the environment, and the chemical industry will all benefit.

Susan Kegley Berkeley, Calif.

Jeff Curtis San Francisco

Miriam Simmons Stillwater, Minn.

 

The article by Marc Reisch on the PBS documentary refers to the chemical industry's commitment to such things as "product stewardship," "zero emissions," and "community outreach."

Is it surprising, however, that the American public would remain skeptical of commitments such as these when they also hear statements such as the following from Nobel Laureate Milton Friedman: "Few trends could so thoroughly undermine the very foundation of our free society as the acceptance by corporate officials of a social responsibility other than to make as much money for their stockholders as possible"?

Peter Hansen Iowa City, Iowa

Jacobs closed her editorial with the statement, "There must be no more secrets and lies." I fully concur. I have seen too many people from our industry die because of exposures to certain chemicals in the workplace. I suspect that in the companies where I have worked, employee exposure was allowed primarily from ignorance, because the same managers who had run the facilities during those days took very different positions when the facts were known. That there was a concerted effort to keep the facts hidden is one of the albatrosses we bear, but it serves us well to remember that there is no shame in honesty. To give priority to profits and jobs over health and safety is false economy; the burden is shifted only in time.

Chemists have always responded well to the challenges of addressing multiple conflicting requirements for the performance of their products and processes. We have learned that incorporating health, safety, and integrity at the design stage has proven time and time again to be most economical for our companies and for our society. We must continue to be open and responsible and to ensure that the general public sees us as that. The latter will be the greater challenge.

Dene Taylor New Hope, Pa.

In her editorial, Jacobs accuses Moyers of "extrapolating from unacceptable chemical exposure of workers decades ago to the conclusion that chemicals today are killing all of us and irrevocably damaging our children." But Moyers made no such claim. In fact, the segment of the program quoted in the editorial carefully avoided concretely establishing such a link. It merely puts facts side by side and allows viewers to draw their own inferences. As a scientist, I know that much of what Moyers said on the subject of the modern chemical industry is unsupported hyperbole. But what Moyers really attacked was industry's credibility-and on this score, the industry has failed very badly in its opportunity to respond.

Of course, we heard the usual defenses: the value of chemistry and chemicals to society, how much the industry has improved, how much more thoroughly chemicals are tested today. What was missing from the industry representatives' statements was any genuine acknowledgment of or regret about the disregard for public and worker safety that various chemical companies have demonstrated over the years. It doesn't take a degree in chemistry to guess what really prevents this kind of acknowledgment; it is the same thing that prevented an appropriate response by the industry in the first place: the fear of liability and the attendant threat of economic loss. Industry protests about its present practices, true or false, ring hollow in the context of its refusal to face up to the facts about its past.

Jonathan Hamlow Minneapolis

EDITOR'S PAGE GUEST EDITORIAL June 4, 2001 Volume 79, Number 23 CENEAR 79 23 pp. 6 ISSN 0009-2347 [Next Story] Dividends From Science

Dennis H. Reilley is chairman, president, and chief executive officer of Praxair. He is also chairman of the American Chemistry Council.

Conducting research is a major part of developing innovative products, improving competitive advantage, and ensuring public health and environmental quality. Investment in research provides essential information to make business and governmental decisions and improve the public's confidence that its best interests are being served.

The members of the American Chemistry Council (ACC) have committed substantial new resources toward the critical objective of evaluating the potential health and environmental impacts of our products and businesses. These voluntary programs include the High Production Volume (HPV) Challenge and the Long-Range Research Initiative (LRI). Through the efforts of ACC, EPA, and Environmental Defense, the pace of screening tests conducted to determine potential health and environmental effects of HPV chemicals has increased globally. By 2004, U.S. companies will have completed testing on the majority of the 2,800 HPV chemicals, and the results will be publicly available. In addition, the industry will act on results in a timely fashion in accordance with the principles of Responsible Care.

In January 1999, ACC members committed more than $100 million over five years to better understand how chemicals interact with the environment and human health. Sixty percent of the LRI research under way is conducted at the CIIT Centers for Health Research (established in 1976 and formerly known as the Chemical Industry Institute of Toxicology), while the remainder is performed at universities and in collaboration with government research agencies.

CIIT scientists frequently collaborate with scientists from other laboratories, including the National Institute of Environmental Health Sciences, EPA, and more than 20 universities and research organizations. In 2000, 50 research articles, review articles, book chapters, and other scientific documents were published, and 39 manuscripts were submitted or were in press by the end of the year. Following are some of the recent research results from CIIT and their impact on public health.

Expanding Knowledge of Inhaled Chemicals: Researchers from CIIT have advanced understanding of the mechanisms by which chemicals enter the body via the respiratory tract, illustrating how the dose in an inhalation animal study can be compared with humans. Ongoing work centers on understanding what populations may be more susceptible to inhaled chemicals--for example, how children's lungs differ from adults' in terms of the doses they would receive, even when breathing in the same environment.

Incorporating State-of-the-Art Science Information: CIIT researchers developed an up-to-date risk assessment on inhaled formaldehyde, working under the latest draft guidelines for cancer risk assessment established by EPA. This new work demonstrated significantly lower risks for various environmental and workplace exposures compared with earlier assessments, which lacked specific data and had to be based on default assumptions.

Applying Advanced Testing Methods: Chloroform is produced in very small amounts during the water chlorination process. Early studies showed that very high doses of chloroform caused cancer in mice and rats, resulting in conservative regulatory actions. Subsequent research at CIIT on the mechanism of chloroform toxicity showed that high doses caused effects in the rodents by killing cells, an effect that does not occur at low-level environmentally relevant doses. This research shows the value of understanding more about mechanisms of carcinogenesis. As a result of this research, EPA has revised the risk assessment of chloroform.

Decisionmakers in government and industry rely on these and other scientific research results to assess the potential hazards of chemicals. Default assumptions must be used in the absence of such information, which can lead to over- or underestimates of risks, neither of which serves the public interest well. The LRI program seeks to improve the scientific foundation of risk assessment. Results from the research are made public regardless of outcome to increase knowledge of the potential effects and exposures of chemicals produced and marketed.

Through efforts such as these, industry, regulators, and the public will have a scientifically improved basis for making decisions that further protect public health and the environment.

Dennis H. Reilley
Praxair Inc.
Views expressed on this page are those of the author and not necessarily those of ACS

EDITOR'S PAGE
June 18, 2001
Volume 79, Number 25
CENEAR 79 25 pp. 5
ISSN 0009-2347

Modesty Does Not Become Us

 Madeleine Jacobs Editor-in-chief The cover of the May 24 issue of Nature caught my eye with this blurb: "Chemists: Too shy for their own good." Not a question, mind you, but a statement.

 I quickly opened up the journal to find not one but two articles devoted to the topic [Nature, 411, 399, 408 (2001)]. The first was an editorial. The gist of the editorial is familiar terrain to C&EN readers. "Chemists and chemistry have never been more vital to science and society than now," it states. But "the discipline is easily misunderstood, and those working in it are frequently underappreciated. ... Chemists have allowed those from outside the field to characterize it--to define what chemistry is and what it is not. To the public, chemical science is too often synonymous with the industry with which it shares its name. So chemistry means belching chimneys and poisoned rivers, not life-saving medicines and space-age materials."

In the article, eminent chemists such as George Whitesides and Stuart Schreiber of Harvard University agree with author David Adam that "new developments in chemistry often seem to end up being appropriated by other disciplines." Adam writes that "it is time for the subject to claim achievements as its own--or risk failing to attract the brightest young scientists."

The solution, Nature says, is that "more of the frontline chemists streaming across the discipline's borders into attention-grabbing multidisciplinary research must make their voices heard. They should proclaim their roles to colleagues and try to ensure that chemical contributions are made known to the media."

Indeed they should. And if you doubt the power of a well-thought-out, sustained effort to influence public opinion, look at the success of the American Chemistry Council's pilot "Good Chemistry Campaign."

Last year, when the Chemical Manufacturers Association changed its name to ACC, it also adopted a slogan, "Good Chemistry Makes It Possible." In February, ACC launched a pilot campaign using this slogan in three locales (C&EN, May 14, page 13). The campaign had four goals: transform the industry identity to one that is dynamic and innovative, achieve recognition for industrywide initiatives such as Responsible Care, communicate the benefits of products made possible by chemistry, and earn the respect of key audiences.

At the ACC general membership meeting earlier this month (page 18), chemical executives were briefed on the pilot in Pittsburgh; Springfield, Mass.; and Iberville Parish, La. A key component was advertising on billboards, on radio, and in newspapers. But equally important was the participation of chemical company employees in community events tailored to the specific locale.

Studies conducted in February, before the $1.5 million campaign got under way, and in May, after the public had been exposed to ads, showed a definite positive shift in favorable perception of the chemical industry. For example, of members of the public over the age of 25 who were polled,14% were favorable toward the chemical industry at the beginning of February, but by late May, 38% held a favorable opinion. ACC is now analyzing the pilot and hopes to expand the program on a national, sustainable scale.

Dow Chemical CEO Michael D. Parker told ACC members: "We are, as an industry, talented, capable people. But we need to marry our great analytical capabilities to our emotion, passion, belief, and commitment" in connecting to the public and communicating the chemical industry's value to society. Parker is profiled in this issue by C&EN's Mike McCoy (page 21). The Nature editorial put it this way: "If more chemists established these connections themselves, and talked up the potential benefits, their contribution would not be so easily overlooked." There is a profound and daunting challenge facing the chemical industry, chemistry as a discipline, and chemists and chemical engineers as professionals. Each of us must make a personal commitment to communicating the value of chemistry. Chemists involved in basic research and in industry have a great story to tell. Let's eschew modesty and tell it.

July 30, 2001
Volume 79, Number 31
CENEAR 79 31 p. 32
ISSN 0009-2347
[Previous Story] [Next Story]

HELGE WEHMEIER
American Chemistry Council's Long-Range Research Initiative chooses areas where it can
make an impact

 MADELEINE JACOBS

In January 1999, American Chemistry Council (ACC) members committed up to $100 million for a five-year program "to increase knowledge of the potential and realized risks that chemicals may have on the health of human and wildlife populations and the environment"--in short, to better understand how chemicals interact with the environment and human health. Since then, the program, called the Long-Range Research Initiative, or LRI, has met with some skepticism by those outside ACC and even by some ACC members. The question most frequently posed is, "Why is ACC doing this?"

Helge H. Wehmeier, president and chief executive officer of Bayer Corp., has an answer--actually, several answers. Wehmeier was involved with LRI's formation and has been chairman of the ACC committee that oversees the development of the program. Last month, he talked with C&EN about the program.

"If we want to convince the public that good chemistry makes it possible, we need to convince them that it is good chemistry."

From the beginning, Wehmeier says, ACC had several goals. One was "enlightened self-interest as part of Responsible Care," he says. "We asked ourselves, 'Will we in the future be forced to do this research anyhow by the government, or will we do the right thing because of our responsibility regarding our products?' We felt that the future of the industry was at stake." But also, he says, ACC wanted to be able to answer the question posed by "Jane Q. Public: namely, 'How do the products of the chemical industry affect my health, the health of my children, and our environment?' Answering this question is an area where the interest of the public and the interest of industry converge."

The early months of the program were spent prioritizing how the limited funding would be allocated. In the beginning, Wehmeier admits, the initiative was very broad based, but ACC soon realized that it needed to narrow its focus.

"We were looking at 10 areas of science: carcinogenicity, respiratory toxicity, etcetera--the so-called 'icities,' " he recalls. "However, this bit-by-bit approach was difficult for the individual citizen to comprehend; they wanted answers to issues like children's health. So we decided that, while the 'icities' were critical to understanding the potential risks from chemicals, we needed to communicate the results of our research in the context of these issues."

Now, the program's focus areas include the following:

*  Development and refinement of methods to improve the evaluation of potential risks of chemicals to public health and the environment. 

*  Sources, transport, fate, and exposure of chemicals in the environment. 

*  Identification and evaluation of potential impact of chemicals on susceptible populations.

Moreover, ACC recognized that "research is like a new frontier," Wehmeier says. "It's constantly moving." Having a set amount of funding "gave us a sense of urgency" to select priority areas for funding, as well as look for potential collaborators," he says.

The program has three objectives: Conduct new research through world-class scientific institutions, develop new testing and screening tools to support risk assessment, and support informed decision-making by government, industry, and citizens.

Sixty percent of the LRI research under way is conducted at the CIIT Centers for Health Research (established in 1976 and formerly known as the Chemical Industry Institute of Toxicology), while the remainder is performed at universities and in collaboration with government research agencies. ACC issues requests for proposals which are peer reviewed by independent, external scientists. Then LRI awards research contracts to institutions based on highest scientific merit and relevance to the chemical industry and the mission of LRI. The requests are posted on ACC's website, http://www.americanchemistry.com.

Research completed by CIIT on the mechanism of chloroform toxicity is an example of work to improve methods in the risk assessment area. Chloroform is produced in small amounts during the water chlorination process. Earlier research showed that very high doses of chloroform caused cancer in mice and rats. CIIT scientists demonstrated that such high doses caused effects in the rodents by killing cells, an event that does not occur at low-level doses. As a result of this work and acceptance by the scientific community, the Environmental Protection Agency revised its risk assessment of chloroform.

Endocrine, reproductive, and developmental toxicology issues make up about 30% of the LRI budget for 200--the largest component of research. The program uses animal models to investigate effects in human health and wildlife. One project involves a study of genistein, a phytoestrogen found in soybeans and soy products (see page 35). CIIT scientists are trying to understand the mechanisms by which genistein may interfere with reproductive development.

Wehmeier is especially pleased that members of the European Chemical Industry Council (CEFIC) and the Japan Chemical Industry Association are also involved with LRI. The International Council of Chemical Associations (ICCA) coordinates research across these three organizations.

ICCA and its member associations have adopted several clear principles, he notes. "For example, the research results are made public regardless of the outcome, and industry has committed to act on these results in a timely fashion."

Wehmeier is well aware that many people doubt the validity and independence of industry-supported research, but he is convinced that the published results will win these skeptics over. "A good start has been made in a process that allows the chemical industry to be proactive--rather than reactive--on matters of truly vital interest to society and to our companies," he says.

And, he adds, LRI needs to be seen in the context of ACC's Responsible Care and the "Good Chemistry Makes It Possible" public image campaign. "If we want to convince the public that good chemistry makes it possible, we need to convince them that it is good chemistry." And that, he says, is what LRI is attempting to find out.

ACS COMMENT
August 6, 2001
Volume 79, Number 32
CENEAR 79 32 p.45
ISSN 0009-2347
[Previous Story] [Next Story]
BETTER THINGS FOR BETTER LIVING THROUGH CHEMISTRY

 ATTILA E. PAVLATH,ACS PRESIDENT

Depending on your age, the above title might bring back memories of times when this statement was proudly displayed by one of the world's largest chemical companies. Unfortunately, over the past several years, increasingly negative publicity has become attached to chemistry by sensationalist headlines and reports. In the end, this company decided (wrongly in my view) to switch instead of fight, and it abandoned this motto. However, this was just one failure to counteract the decline of the public image of chemistry. Many of the practitioners of chemistry also took the easier way out by remaining silent.

We should not apologize for chemistry; we should proudly publicize what chemistry has contributed to our lives. 

Initially, we tended to dismiss these attacks as irresponsible, tabloid-style sensationalism that should not be dignified with an answer. As the "politically correct" trend gained momentum, the silence was maintained by many for fear of being ridiculed. Only a handful of chemical professionals spoke up, but their rational, middle-of-the-road arguments were usually ignored. Chemical spills, mishaps, and accidents tend to be reported with three-inch headlines, regardless of the magnitude of their impact. Have you ever seen a similar headline about the discovery of a new polymer--or any chemical product, for that matter--that made life easier?

It is now time to change our attitude toward these attacks. I believe that this is not just an option, it is a must! We should not apologize for chemistry; we should proudly publicize what chemistry has contributed to our lives. We must make the public realize what life would be like today without the practical contributions of chemistry.

In 1850, the large majority of the U.S. population was needed to produce enough food for the whole nation. Today, as a result of various contributions from chemistry, only 2% of the population is involved in food production, not just for ourselves, but for export as well. Yes, there were and are problems, but in life there is no "zero risk," no "perfect" solution. Even the most beneficial, highly heralded action, scientific or social, is likely to have some drawback. But I am proud to point out that chemistry always addressed the problems that might have been derived from some previous chemical discovery and developed solutions for them. For every negative effect, there are at least 100 beneficial ones. Unfortunately, the large part of the general public responds to the size of the headlines.

As I indicated in my presidential message in January, I want to improve the public image of chemistry. I appointed a task force that has been working hard for more than a year to collect those developments in chemical technology over the past 125 years that have improved our lives. The task force's diligent work resulted in a very impressive proof of the importance of chemistry in every aspect of life. These areas include energy, transportation, environment, food, health, communication, and material--with dozens of examples in each.

The results are being summarized in the form of a novel exhibit that will be first shown at the fall ACS national meeting in Chicago, Aug. 26-30. The exhibit emphasizes, in an easily understandable way, these discoveries and their effects on our lives. It will be given the widest possible publicity at the meeting. I invite you to visit the exhibit, which will be in the Vista Room of the McCormick Place Convention Center.

The next step is to translate this display into a permanent testimony for chemistry in various ways, and I need your help and suggestions on how to get this information efficiently to the general public. Those of us who will attend the meeting do not have to be convinced of the value of chemistry. It is the general, nonscientific public whom we must reach. This is just the beginning.

FOR MORE INFORMATION 

From time to time, ACS committee chairs and national officers write comments for C&EN. ACS members who wish to read more comments can find them on the Web on C&EN Online at http://pubs.acs.org/cen/html/acscomments.html.We must continue to be on the alert on two fronts. One is to find improved ways to publicize new achievements in chemical technologies with the potential for better things for better living. This is what John and Jane Q. Public understand, even if they did not take chemistry in high school. The other is to be alert for misleading, sensationalist headlines. While some of the media operate on the "good news is no news" principle, the major outlets are responsible and are willing to listen to rational counteropinions. This news might not appear with the same prominence, but it will present a different view to the public. This must be an ongoing, large-scale operation.

Last year, on the initiative of then-president Daryle Busch, ACS established a symbiotic relationship with the Green Chemistry Institute. I am working on creating a coalition for a Center for the Public Image of Chemistry, which would have the dual responsibility of publicizing facts and counteracting sensationalist half-truths. This would also serve as a source for middle-of-the-road, responsible journalism. There will always be some supermarket-tabloid reporting, but this way we can present a much-needed balance of views to the public--views based on logic and facts rather than on emotion and myths.

 Views expressed on this page are those of the author and not necessarily those of ACS.

 

Susan E. Kegley, Ph.D., Staff Scientist/Program Coordinator
Pesticide Action Network, North America Regional Center
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