The effect of glyphosate on cell cycle controls

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Subject:  The effect of glyphosate on cell cycle controls
Date:     Thu, 30 May 2002 08:36:59 -0400
From:      Stephen Tvedten <steve@getipm.com>
Organization:     Get Set Inc. (www.getipm.com)

To:     Paul Helliker <phelliker@cdpr.ca.gov>
          Director, State of California, Department of Pesticide Regulation 

cc:    Christine Whitman whitman.christine@epa.gov

Dear Mr. Helliker, Since it has been admitted that glyphosate adversely effects the mitochondria and that OPs interfere with the ADP/ATP and therefore the Cyclic AMP, etc, systems, we imagine that this study/article should come as no surprise to you!!
 

The study below shows the effect of glyphosate on cell cycle controls.The implications on human health are profound. Such studies should not be ignored by regulators!
 

Chem Res Toxicol 2002 Mar;15(3):326-31 Pesticide Roundup Provokes Cell Division Dysfunction at the Level of CDK1/Cyclin B Activation.  Marc J, Mulner-Lorillon O, Boulben S, Hureau D, Durand G, Belle R. Station Biologique de Roscoff, Universite Pierre et Marie Curie (UFR 937), Centre National de la Recherche Scientifique (CNRS, UMR 7127), BP 74, 29682 Roscoff Cedex, France.
 

To assess human health risk from environmental chemicals, we have studied the effect on cell cycle regulation of the widely used glyphosate-containing pesticide Roundup. As a model system we have used sea urchin embryonic first divisions following fertilization, which are appropriate for the study of universal cell cycle regulation without interference with transcription. We show that 0.8% Roundup (containing 8 mM glyphosate) induces a delay in the kinetic of the first cell cleavage of sea urchin embryos. The delay is dependent on the concentration of Roundup. The delay in the cell cycle could be induced using increasing glyphosate concentrations (1-10 mM) in the presence of a subthreshold concentration of Roundup 0.2%, while glyphosate alone was ineffective, thus indicating synergy between glyphosate and Roundup formulation products. The effect of Roundup was not lethal and involved a delay in entry into M-phase of the cell cycle, as judged cytologically. Since CDK1/cyclin B regulates universally the M-phase of the cell cycle, we analyzed CDK1/cyclin B activation during the first division of early development. Roundup delayed the activation of CDK1/cyclin B in vivo.
 

Roundup inhibited also the global protein synthetic rate without preventing the accumulation of cyclin B. In summary, Roundup affects cell cycle regulation by delaying activation of the CDK1/cyclin B complex, by synergic effect of glyphosate and formulation products.
 

Considering the universality among species of the CDK1/cyclin B regulator, our results question the safety of glyphosate and Roundup on human health.
 

Well Mr. Helliker, What are you going to do?
 

Respectfully, Stephen L. Tvedten

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