Classes and Examples of Chemicals Causing Immunologic Changes
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Classes and Examples of Chemicals Causing Immunologic Changes
Date:
Thu, 5 Sep 2002 09:49:01 -0400
From:
Stephen Tvedten <steve@getipm.com>
Organization: Get Set Inc. (www.getipm.com)
To: Paul Helliker <phelliker@cdpr.ca.gov>
Director, State of California, Department of Pesticide
Regulation
cc: Christine Whitman
whitman.christine@epa.gov
cc: Brian J. Foster
bfoster@swlaw.com
To Bunny Snow's knowledge, the US EPA has not required testing pesticides which suppression of immune processes during registration. Hence, they cannot claim they are safe, even if used as directed on the label. The following comes from the National Academy of Sciences Press: ''There is increasing awareness and concern within the scientific and public communities that chemical pollutants can suppress immune processes and thus cause increased development of neoplastic and infectious diseases. Adverse effects on humans treated with immunosuppressive drugs, numerous studies employing experimental animals, and, to a lesser extent, isolated cases of altered immune function in humans inadvertently or occupational exposed to xenobiotic substances support these concerns....'' http://books.nap.edu/books/0309043891/html/63.html . The online book is entitled, ''Biologic Markers in Immunotoxicology (1992)''.
On page 70 is Table 5-3 Classes and Examples of Chemicals Causing Immunologic Changes and this includes Polyhalogenanated Aromatic Hydrocarbons including TCDD, PBBs, PCDF, PCBs, hexachlorobenzene.
Heavy Metals including. lead, calcium, arsenic, methyl mercury.
Solvents (aromatic hydrocarbons) such as benzene, toluene Polycyclic Aromatic Hydrocarbons including DMBA [dimethylbenzanthracene]; B[a]P [benzo[a]pyrene]; MCA [methylcholanthrene].
Pesticides including carbofuran, chlordane, and malathion.
Organotins include TBTO [bis(tris-n-butylin)oxide}.
Aromatic amines include Benzidene, acetyl aminofluorene.
Oxidant gases include: Nitrogen dioxide, ozone, sulfur, dioxide Particles include: silica, asbestos
Natural products include: selected vitamins, antibiotics, vinca alkaloids, estrogen, plant alkaloids, mycotoxins.
Drugs of abuse include: ethanol, cannabinoids, cocaine, opiods
Therapeutic drugs include: Diphenylhydantoin, lithium
Others are: Nitrosamine, BHA [butylated hydroxyanisole].
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