D-Limonene toxicity
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Here to Add CommentA few years ago SafeScience Inc. reviewed the literature on d-limonene and
raised both the suspected carcinogen status and possible contamination of
d-limonene by trace pesticide residues (d-limonene is often produced from the
rinds of citrus fruits/citrus oils). SafeScience Inc. decided not to formulate
with d-limonene [(R)-1-METHYL-4-(1-METHYLETHENYL)- CYCLOHEXENE (9CI) ].
Under the conditions of 2-year gavage study posted on the NTP site, there was
"clear evidence" of carcinogenic activity of d-limonene for male F344/N rats,
as shown by increased incidences of tubular cell hyperplasia, adenomas, and
adenocarcinomas of the kidney. Interestingly, no adverse problems for female
rats. For those interested in additional details please visit this links:
http://ntp-server.niehs.nih.gov/htdocs/LT-studies/tr347.html
http://ntp-server.niehs.nih.gov/htdocs/levels/tr347levels.html
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Subject: Re: d-limonene
From: "shp" <shp@uml.edu>
Date: Thu, 31 Oct 2002 13:47:21 -0500
X-Message-Number: 7
The following National Toxics Program reference suggests that concentrated
d-limonene has a number of concerns.
Reference:
NTP CHEMICAL REPOSITORY
D-LIMONENE
http://ntp-server.niehs.nih.gov/htdocs/CHEM_H&S/NTP_Chem5/Radian5989-27-5.html
"Since this chemical is a known or suspected carcinogen you should contact a
physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route of
exposure."
Catherine Galligan
SHP Clearinghouse Manager
978-934-3386
http://www.sustainablehospitals.org
--
Bill Ravanesi MA, MPH
Boston Campaign Director
Health Care Without Harm
19 Pleasantview Ave.
Longmeadow, MA 01106
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